Perimenopause: signs and clinical management
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Perimenopause is the phase preceding menopause. It typically begins around age 43-45, but can also appear earlier or later: each woman has her own timing. It's a natural transition period, during which the body begins to gradually change. Its duration varies, averaging 3 to 5 years. [1] .
Perimenopause represents the final stage of the fertile years (premenopause) and the beginning of the transition to menopause. As long as menstrual periods are still present, even if irregular, you are in perimenopause and not yet menopause. Symptoms can vary greatly from woman to woman, both in type and intensity. The most common are:
- Irregular menstrual cycle;
- First hot flashes;
- Night sweats;
- Sleep disturbances;
- Mood swings or increased irritability;
- Anxiety or feeling of mental confusion;
- Joint pain;
- Bloating or minor digestive discomfort.
These changes are mainly linked to fluctuations in estrogen, the female hormone, which begins to gradually decline. This isn't a "problem," but rather a phase of the body's adaptation. [2] [3] .
Perimenopause can impact your quality of life: disturbed sleep, fatigue, mood or weight changes can impact your daily life, work, and relationships. Intervening early can help you navigate this phase with greater balance, especially in anticipation of menopause itself.
Taking care of yourself right now means listening to your body's signals, adopting a balanced lifestyle, considering targeted supplements if necessary, and consulting with your trusted gynecologist.
Every woman experiences perimenopause differently. The important thing is not to feel alone and not to ignore the signs: with the right support, it's possible to face this phase with awareness and serenity.
Bibliography and Scientific Studies
[1] SM McKinlay, “The normal menopause transition: an overview,” Maturitas , vol. 23, no. 2, pp. 137–145, Mar. 1996.
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[2] P. Patel, S. Patil, and N. Kaur, “Estrogen and Metabolism: Navigating Hormonal Transitions from Perimenopause to Postmenopause,” J. Midlife Health , vol. 16, no. 3, pp. 247–256, Jul. 2025.
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[3] J. Turek and Ł. Gąsior, “Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders,” Pharmacological Reports , vol. 75, no. 1, pp. 32–43, Feb. 2023.
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